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Dhivya, L. S.
- Protective role of Borreria hispida against Galactosamine Induced Diabetic Cataract
Abstract Views :145 |
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Authors
M. Sumithra
1,
Shatabdi Choudhury
1,
L. S. Dhivya
1,
M. Nithiyanand
1,
Jimson Zachariah
1,
Sharmila
1
Affiliations
1 Dept of Pharmacology, SRM College of Pharmacy, Kasttankulathur, Kancheepuram District, Tamilnadu, IN
1 Dept of Pharmacology, SRM College of Pharmacy, Kasttankulathur, Kancheepuram District, Tamilnadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 3 (2019), Pagination: 1235-1238Abstract
Cataract is the major cause of blindness all over the world, nearly 42% of visual impairment occurs due to diabetic associated complications in the eye. Borreria hispida, belonging to Rubiaceae family was used to treat eye infections by folklore system of medicine in India. This study was aimed to create scientific evidence for the anti-cataract activity of hydroalcoholic leaf extract of Borreria hispida (HAEBH) in diabetes induced cataract using goat lens. Cataract was induced using galactosamine in goat eyes lens. In this study, isolated goat lenses were suspended in bovine serum albumin. Totally sixteen lenses were selected, each group containing four lenses - normal control (distilled water treated lens), galactosamine treated lens, 1mg/ml of the hydroalcoholic extract of Borreria hispida leaves extract treated lens (HAEBH) and finally 1mg/ml of standard drug atropine treated lens. The opacification of lens were monitored in all the sixteen lenses. Among these, the anticataract activity of Borreria hispida was strengthened by the reduction in the deposition of proteins which is involved in the opacification of lens compared to galactosamine treated lens. The extract shown effective anticataract effect similar to that of standard group. The hydroalcoholic extract of Borreria hispida possess anticataract activity may be due to inhibition of Aldose Reductase enzyme involved in the polyol pathway which has a prime role in developing diabetes induced cataract. Further studies has to be carried out to isolate the prominent biomolecule responsible to control diabetes associated cataract.Keywords
Borreria hispida, Galactosamine, Aldose Reductase, Polyol Pathway.
References
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Abstract Views :155 |
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Authors
Affiliations
1 Dr. APJ Kalam Research Lab, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Kancheepuram, Tamil Nadu, IN
2 Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat, IN
3 Dr. APJ Kalam Research Lab, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Kancheepuram, Tamil Nadu Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Kancheepuram, Tamil Nadu, IN
1 Dr. APJ Kalam Research Lab, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Kancheepuram, Tamil Nadu, IN
2 Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat, IN
3 Dr. APJ Kalam Research Lab, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Kancheepuram, Tamil Nadu Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Kancheepuram, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 22, No 3 (2022), Pagination: 457 - 471Abstract
The objective of the work is to identify a natural origin compound that could have an anti-tubercular effect, thereby preventing the infection in humans using computational approach. Our focus was to find a inhibitor for Enoyl- acyl carrier reductase enzyme and hence chemically diverse scaffolds from plants origin were selected. Admet parameters were performed for the compounds, and the top nine compounds among 50 compounds were found to be non-carcinogenic. The pharmacological predicted activity (Pa) of few compounds such as 14-Deoxy-11,12 didehydroandrographolide, Terflavin B, and Liquirtin was found to be more active when compared with that of the standard reference. Further more the synthesis of these active compounds derivatives can be investigated theoretical followed by its synthesis and evaluation by in vitro activity against the InhA could be of interest.
Keywords
InhA, Liquirtin, Mycobacterium tuberculosis, Molecular Docking, Terflavin B.Full Text
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